CGMP Ampoule Filling And Sealing Machine For South Africa’s Pharma Industry

Leading Ampoule Filling & Sealing Solutions by Technogen Enterprise – Now in South Africa

Technogen Enterprise presents its advanced range of automatic ampoule filling and sealing machines, designed to meet the evolving demands of the pharmaceutical injectable industry. With multiple head configurations and cutting-edge sealing systems, our machines deliver consistent performance, high accuracy, and regulatory compliance—ideal for both domestic and export-focused pharmaceutical producers in South Africa.

Whether you're producing liquid injectables, vaccines, or sterile products, our ampoule filling and sealing machines are the preferred choice for companies across Johannesburg, Durban, Cape Town, Pretoria, Port Elizabeth, and other key pharmaceutical manufacturing hubs.

Why Choose Our Ampoule Filling and Sealing Machine?

Technogen’s TGAFS Series is designed with the pharmaceutical industry's critical needs in mind—sterility, precision, and efficiency. The machine combines automated ampoule handling, filling, and flame sealing in one streamlined process with minimal operator intervention.

This machine is ideal for:

• Pharmaceutical injectable lines

• Biotech companies

• Sterile ampoule production

• Vaccine manufacturing

• Veterinary injectables

With production capabilities ranging from 60 to 160 ampoules per minute, our machines meet the needs of both small-batch producers and high-volume pharma manufacturers.

Salient Features of Technogen's Ampoule Filling and Sealing Machine

Technogen’s ampoule machinery delivers world-class performance and operator-friendly features tailored for sterile production environments.

• ✅ cGMP-Compliant Design
  Machine is built with full cGMP compliance, ensuring hygiene, safety, and regulatory alignment.

• ✅ Multiple Head Options
  Available in 4-head, 6-head, and 8-head configurations, depending on your production requirements.

• ✅ No Ampoule – No Fill Mechanism
  Prevents product wastage and ensures product is only filled when ampoules are correctly positioned.

• ✅ Pre & Post Nitrogen Gassing
  Controlled gassing improves product stability and extends shelf life of sensitive injectables.

• ✅ Induction Gear Motor & Worm Gear Box
  Ensures smooth synchronization between ampoule transport, filling, and sealing stations.

• ✅ Anti-Foaming Dive Nozzles
  Minimizes spillage and foam formation during high-speed filling.

• ✅ Draw Jaw Sealer with Pusher Mechanism
  Delivers consistent flame sealing and automatic tray ejection of sealed ampoules.

• ✅ Emergency Stop Function
  Safety-first operation with a dedicated emergency stop button.

• ✅ Counting Mechanism
  In-built counter tracks production output for operational efficiency.

• ✅ Flexible Output Range
  Capable of filling ampoules from 1 ml to 10 ml, accommodating most pharmaceutical needs.

Add-On Features

For higher levels of automation and safety, we offer optional configurations:

• PLC-HMI Interface
  Intuitive touchscreen control with programmable settings for quick changeovers.

• Toughened Glass or Acrylic Safety Enclosure
  Protects operators from open flames and ensures compliance with safety standards.

Machine Working Principle – At a Glance

Here’s how the TGAFS series operates in a fully synchronized manner:

1. Infeed Tray Feeding

• Empty ampoules are loaded onto the infeed tray, guided into the transport mechanism.

2. Ampoule Indexing

• Ampoules are transported to the filling station using a precision star wheel or conveyor.

3. Pre-Gassing (Optional)

• Nitrogen gas is injected into the ampoules before filling to displace oxygen.

4. Filling Process

• Liquid product is filled with ±1% accuracy using diving nozzles that prevent foam and splashing.

5. Post-Gassing (Optional)

• A second dose of nitrogen may be applied after filling to protect sensitive formulations.

6. Flame Sealing

• Ampoules are rotated and passed through a draw jaw flame sealer, ensuring tight, uniform sealing.

7. Pusher Mechanism

• Sealed ampoules are gently pushed into the outfeed tray for collection.

This process is fully synchronized, minimizing operator workload and reducing human error.

Technical Specifications of TGAFS Series

Applications Across South African Industries

This machine is purpose-built for liquid injectable manufacturing, and is widely applicable to:

• Pharmaceutical Companies producing human injectables

• Veterinary Pharma Manufacturers

• Biotech Labs working on vaccine development

• Contract Manufacturing Organizations (CMOs)

• R&D and Pilot-Scale Facilities

Its compact size and scalable output make it perfect for both small-scale facilities in Pretoria and high-capacity plants in Cape Town, Durban, or Johannesburg.

Advantages for South African Market

✅ Localized Support

We provide full support across South Africa, with logistics partnerships in Gauteng, KwaZulu-Natal, Western Cape, and Eastern Cape regions.

✅ Cost-Efficient Automation

Technogen’s machines offer exceptional price-performance ratio for startups and SMEs.

✅ Flexible Configuration

Choose from 4, 6, or 8-head models based on your output requirement and facility space.

✅ Energy Efficient

Designed for low power consumption, aligned with South Africa’s push for sustainable operations.

Seamless Integration with Other Pharma Equipment

Our ampoule filling line can be integrated with:

• Ampoule washing machines

• Sterilizing tunnels

• Labelling machines

• Visual inspection units

• Cartoning & packing systems

This ensures a continuous production line from sterilization to final packaging.

Maintenance & Operator Safety

The TGAFS machines are engineered with:

• Easy-access covers for maintenance

• Emergency safety stop button

• Minimal change parts required for size switching

After-Sales Service & Support

We understand the operational importance of reliability and uptime. That’s why Technogen Enterprise ensures:

• Spare part availability

• Quick dispatch from India to South Africa

• Onsite or virtual installation & training

• 24/7 remote troubleshooting support

Order Now – Upgrade Your Injectable Production Line

Whether you're setting up a new ampoule filling line in Johannesburg or expanding your existing unit in Durban, Technogen’s Ampoule Filling and Sealing Machine is the perfect partner for your growth.

Choose between:

• ✅ TGAFS-60 (4 Head) – For small to medium batches

• ✅ TGAFS-120 (6 Head) – For mid-volume production

• ✅ TGAFS-180 (8 Head) – For high-speed, large-scale operations